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Nanocarriers: Capturing “Extraordinary” Soft‐Assembled Charge‐Like Polypeptides as a Strategy for Nanocarrier Design (Adv. Mater. 39/2017)
Author(s) -
DuroCastano Aroa,
Nebot Vicent J.,
NiñoPariente Amaya,
Armiñán Ana,
ArroyoCrespo Juan J.,
Paul Alison,
FeinerGracia Natalia,
Albertazzi Lorenzo,
Vicent María J.
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201770280
Subject(s) - nanocarriers , materials science , nanotechnology , star polymer , polymer , star (game theory) , drug , drug delivery , pharmacology , medicine , physics , astrophysics , composite material , polymerization
A novel strategy developed by Vicent J. Nebot, María J. Vicent, and co‐workers in article number 1702888 to produce nanosized drug carriers may improve the anticancer drug activity of polymer therapeutics and patient treatment. The discovery of an attractive force between negatively charged star‐shaped‐polypeptides allows single stars to self‐assemble into unprecedented larger spherical structures with enhanced pharmacokinetic characteristics. Furthermore, selective lymph‐node accumulation of these carriers may lead to applications in anti‐metastatic and immunotherapeutic strategies.