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Drug Delivery: Engineering the Surface of Smart Nanocarriers Using a pH‐/Thermal‐/GSH‐Responsive Polymer Zipper for Precise Tumor Targeting Therapy In Vivo (Adv. Mater. 36/2017)
Author(s) -
Zhang Penghui,
Wang Yan,
Lian Jing,
Shen Qi,
Wang Chen,
Ma Bohan,
Zhang Yuchao,
Xu Tingting,
Li Jianxin,
Shao Yongping,
Xu Feng,
Zhu JunJie
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201770263
Subject(s) - nanocarriers , materials science , photothermal therapy , drug delivery , in vivo , nanotechnology , glutathione , targeted drug delivery , polymer , zipper , anticancer drug , drug , biophysics , chemistry , pharmacology , biochemistry , medicine , computer science , biology , microbiology and biotechnology , composite material , enzyme , algorithm
In article number 1702311 , Feng Xu, Jun‐Jie Zhu, and co‐workers tune nanocarrier surface compositions on command for precise tumor targeting by way of pH‐/thermal‐/glutathione‐responsive polymer zippers. The nanocarriers remain stealthy during blood circulation, but their surfaces are activated by the acidic microenvironment and photothermal heating at tumor sites for enhanced cellular uptake and efficient drug release.