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Polymer Nanoparticles: Synthesis and Assembly of Click‐Nucleic‐Acid‐Containing PEG–PLGA Nanoparticles for DNA Delivery (Adv. Mater. 24/2017)
Author(s) -
Harguindey Albert,
Domaille Dylan W.,
Fairbanks Benjamin D.,
Wagner Justine,
Bowman Christopher N.,
Cha Jennifer N.
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201770170
Subject(s) - plga , nucleic acid , materials science , glycolic acid , nanoparticle , click chemistry , peg ratio , dna , biodegradable polymer , nanotechnology , polymer , gene delivery , lactic acid , combinatorial chemistry , biochemistry , genetic enhancement , chemistry , polymer chemistry , biology , gene , bacteria , finance , economics , composite material , genetics
Co‐delivery of both chemotherapy drugs and siRNA from a single delivery vehicle can have a significant impact on cancer therapy. In article number 1700743 , Jennifer Cha and co‐workers demonstrate that significant amounts of DNA can be encapsulated within poly(lactic‐ co ‐glycolic acid) (PLGA)‐containing nanoparticles through the use of a new synthetic DNA analog, click nucleic acids (CNAs), demonstrating their potential as carriers for chemotherapy agents and gene silencers.