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Nanovaccines: Multistaged Nanovaccines Based on Porous Silicon@Acetalated Dextran@Cancer Cell Membrane for Cancer Immunotherapy (Adv. Mater. 7/2017)
Author(s) -
Fontana Flavia,
Shahbazi MohammadAli,
Liu Dongfei,
Zhang Hongbo,
Mäkilä Ermei,
Salonen Jarno,
Hirvonen Jouni T.,
Santos Hélder A.
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201770049
Subject(s) - materials science , adjuvant , cancer , cancer immunotherapy , antigen , membrane , cancer cell , immunotherapy , nanotechnology , immunology , medicine , biology , biochemistry
In article 1603239, Flavia Fontana, Hélder A. Santos, and co‐workers develop an innovative cancer nanovaccine by merging the adjuvant properties of the nanoparticles produced by nanoprecipitation in a microfluidic glass capillary device with high reproducibility, together with a biomimetic source of antigens derived from cancer‐cell membranes. The nanovectors induce maturation of antigen‐presenting cells and secretion of pro‐inflammatory cytokines in vitro.