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2D Materials: Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues (Adv. Mater. 5/2017)
Author(s) -
Ma YunHan,
Dou WeiTao,
Pan YuFei,
Dong LiWei,
Tan YeXiong,
He XiaoPeng,
Tian He,
Wang HongYang
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201770034
Subject(s) - hepatocellular carcinoma , materials science , peptide , biomarker , cancer research , supramolecular chemistry , nanotechnology , biology , chemistry , biochemistry , crystallography , crystal structure
In article 1604253, X.‐P. He, H.‐Y. Wang, and co‐workers describe supramolecular assembly between water‐soluble 2D MoS 2 and a peptide probe producing a 2D peptidosheet suited for the profiling of different carcinoma tissues over healthy tissues in clinical specimens. The dragon symbolizes the peptide ligand selective for CD47 on the surface of cancer tissues. The dragon is originally “hidden” in the 2D MoS 2 materials, but once it detects cancer tissues, it is set free to shed light on the cancer, rather than normal tissues without CD47 expression, through releasing its fire (fluorescence).