Premium
Methylxanthine Drug Monitoring with Wearable Sweat Sensors
Author(s) -
Tai LiChia,
Gao Wei,
Chao Minghan,
Bariya Mallika,
Ngo Quynh P.,
Shahpar Ziba,
Nyein Hnin Y. Y.,
Park Hyejin,
Sun Junfeng,
Jung Younsu,
Wu Eric,
Fahad Hossain M.,
Lien DerHsien,
Ota Hiroki,
Cho Gyoujin,
Javey Ali
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201707442
Subject(s) - wearable computer , drug , drug detection , caffeine , sweat , pharmacology , medicine , biomedical engineering , computer science , embedded system , chemistry , chromatography
Drug monitoring plays crucial roles in doping control and precision medicine. It helps physicians tailor drug dosage for optimal benefits, track patients' compliance to prescriptions, and understand the complex pharmacokinetics of drugs. Conventional drug tests rely on invasive blood draws. While urine and sweat are attractive alternative biofluids, the state‐of‐the‐art methods require separate sample collection and processing steps and fail to provide real‐time information. Here, a wearable platform equipped with an electrochemical differential pulse voltammetry sensing module for drug monitoring is presented. A methylxanthine drug, caffeine, is selected to demonstrate the platform's functionalities. Sweat caffeine levels are monitored under various conditions, such as drug doses and measurement time after drug intake. Elevated sweat caffeine levels upon increasing dosage and confirmable caffeine physiological trends are observed. This work leverages a wearable sweat sensing platform toward noninvasive and continuous point‐of‐care drug monitoring and management.