Premium
Monolayer Nanosheets with an Extremely High Drug Loading toward Controlled Delivery and Cancer Theranostics
Author(s) -
Peng Liuqi,
Mei Xuan,
He Jun,
Xu Jiekun,
Zhang Weiku,
Liang Ruizheng,
Wei Min,
Evans David G.,
Duan Xue
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201707389
Subject(s) - materials science , drug delivery , biocompatibility , nanotechnology , nanomaterials , nanomedicine , in vivo , indocyanine green , doxorubicin , controlled release , nanoparticle , medicine , chemotherapy , microbiology and biotechnology , surgery , metallurgy , biology
2D nanomaterials have attracted considerable research interest in drug delivery systems, owing to their intriguing quantum size and surface effect. Herein, Gd 3+ ‐doped monolayered‐double‐hydroxide (MLDH) nanosheets are prepared via a facile bottom‐up synthesis method, with a precisely controlled composition and uniform morphology. MLDH nanosheets as drug carrier are demonstrated in coloading of doxorubicin and indocyanine green (DOX&ICG), with an ultrahigh drug loading content (LC) of 797.36% and an encapsulation efficiency (EE) of 99.67%. This is, as far as it is known, the highest LC level at nearly 100% of EE among previously reported 2D drug delivery systems so far. Interestingly, the as‐prepared DOX&ICG/MLDH composite material shows both pH‐controlled and near‐infrared‐irradiation‐induced DOX release, which holds a promise in stimulated drug release. An in vivo dual‐mode imaging, including near‐infrared fluorescence and magnetic resonance imaging, enables a noninvasive visualization of distribution profiles at the tumor site. In addition, in vitro and in vivo therapeutic evaluations demonstrate an excellent trimode synergetic anticancer activity and superior biocompatibility of DOX&ICG/MLDH. Therefore, MLDH nanosheets provide new perspectives in the design of multifunctional nanomedicine, which shows promising applications in controlled drug delivery and cancer theranostics.