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Self‐Assembly of Enzyme‐Like Nanofibrous G‐Molecular Hydrogel for Printed Flexible Electrochemical Sensors
Author(s) -
Zhong Ruibo,
Tang Qian,
Wang Shaopeng,
Zhang Hongbo,
Zhang Feng,
Xiao Mingshu,
Man Tiantian,
Qu Xiangmeng,
Li Li,
Zhang Weijia,
Pei Hao
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201706887
Subject(s) - materials science , bioelectronics , glucose oxidase , self healing hydrogels , nanotechnology , fabrication , nanofiber , immobilized enzyme , electrode , biosensor , electrochemistry , polyaniline , conductive polymer , polymer , polymer chemistry , composite material , polymerization , chemistry , organic chemistry , enzyme , medicine , alternative medicine , pathology
Conducting hydrogels provide great potential for creating designer shape‐morphing architectures for biomedical applications owing to their unique solid–liquid interface and ease of processability. Here, a novel nanofibrous hydrogel with significant enzyme‐like activity that can be used as “ink” to print flexible electrochemical devices is developed. The nanofibrous hydrogel is self‐assembled from guanosine (G) and KB(OH) 4 with simultaneous incorporation of hemin into the G‐quartet scaffold, giving rise to significant enzyme‐like activity. The rapid switching between the sol and gel states responsive to shear stress enables free‐form fabrication of different patterns. Furthermore, the replication of the G‐quartet wires into a conductive matrix by in situ catalytic deposition of polyaniline on nanofibers is demonstrated, which can be directly printed into a flexible electrochemical electrode. By loading glucose oxidase into this novel hydrogel, a flexible glucose biosensor is developed. This study sheds new light on developing artificial enzymes with new functionalities and on fabrication of flexible bioelectronics.