Premium
Tissue Mimicry in Morphology and Composition Promotes Hierarchical Matrix Remodeling of Invading Stem Cells in Osteochondral and Meniscus Scaffolds
Author(s) -
Stuckensen Kai,
Schwab Andrea,
Knauer Markus,
MuiñosLópez Emma,
Ehlicke Franziska,
Reboredo Jenny,
GraneroMoltó Froilán,
Gbureck Uwe,
Prósper Felipe,
Walles Heike,
Groll Jürgen
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201706754
Subject(s) - materials science , meniscus , tissue engineering , mesenchymal stem cell , matrix (chemical analysis) , stromal cell , biomedical engineering , stem cell , extracellular matrix , regeneration (biology) , microbiology and biotechnology , nanotechnology , anatomy , biology , pathology , medicine , composite material , physics , incidence (geometry) , optics
An integral approach toward in situ tissue engineering through scaffolds that mimic tissue with regard to both tissue architecture and biochemical composition is presented. Monolithic osteochondral and meniscus scaffolds are prepared with tissue analog layered biochemical composition and perpendicularly oriented continuous micropores by a newly developed cryostructuring technology. These scaffolds enable rapid cell ingrowth and induce zonal‐specific matrix synthesis of human multipotent mesenchymal stromal cells solely through their design without the need for supplementation of soluble factors such as growth factors.