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Light‐Responsive Biodegradable Nanorattles for Cancer Theranostics
Author(s) -
Li Chunxiao,
Zhang Yifan,
Li Zhiming,
Mei Enci,
Lin Jing,
Li Fan,
Chen Cunguo,
Qing Xialing,
Hou Liyue,
Xiong Lingling,
Hao Hui,
Yang Yun,
Huang Peng
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201706150
Subject(s) - materials science , photothermal therapy , nanotechnology , biocompatibility , mesoporous silica , microbubbles , nanorod , photoacoustic imaging in biomedicine , nanoparticle , biomedical engineering , mesoporous material , ultrasound , chemistry , optics , medicine , biochemistry , physics , acoustics , metallurgy , catalysis
Cancer nanotheranostics, integrating both diagnostic and therapeutic functions into nanoscale agents, are advanced solutions for cancer management. Herein, a light‐responsive biodegradable nanorattle‐based perfluoropentane‐(PFP)‐filled mesoporous‐silica‐film‐coated gold nanorod (GNR@SiO 2 ‐PFP) is strategically designed and prepared for enhanced ultrasound (US)/photoacoustic (PA) dual‐modality imaging guided photothermal therapy of melanoma. The as‐prepared nanorattles are composed of a thin mesoporous silica film as the shell, which endows the nanoplatform with flexible morphology and excellent biodegradability, as well as large cavity for PFP filling. Upon 808 nm laser irradiation, the loaded PFP will undergo a liquid–gas phase transition due to the heat generation from GNRs, thus generating nanobubbles followed by the coalescence into microbubbles. The conversion of nanobubbles to microbubbles can improve the intratumoral permeation and retention in nonmicrovascular tissue, as well as enhance the tumor‐targeted US imaging signals. This nanotheranostic platform exhibits excellent biocompatibility and biodegradability, distinct gas bubbling phenomenon, good US/PA imaging contrast, and remarkable photothermal efficiency. The results demonstrate that the GNR@SiO 2 ‐PFP nanorattles hold great potential for cancer nanotheranostics.