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Materials for Neural Differentiation, Trans‐Differentiation, and Modeling of Neurological Disease
Author(s) -
Gong Lulu,
Cao Lining,
Shen Zhenmin,
Shao Li,
Gao Shaorong,
Zhang Chao,
Lu Jianfeng,
Li Weida
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201705684
Subject(s) - cellular differentiation , neural cell , induced pluripotent stem cell , neural stem cell , neuroscience , regeneration (biology) , neuron , somatic cell , materials science , cell , biology , nanotechnology , stem cell , microbiology and biotechnology , embryonic stem cell , biochemistry , gene
Neuron regeneration from pluripotent stem cells (PSCs) differentiation or somatic cells trans‐differentiation is a promising approach for cell replacement in neurodegenerative diseases and provides a powerful tool for investigating neural development, modeling neurological diseases, and uncovering the mechanisms that underlie diseases. Advancing the materials that are applied in neural differentiation and trans‐differentiation promotes the safety, efficiency, and efficacy of neuron regeneration. In the neural differentiation process, matrix materials, either natural or synthetic, not only provide a structural and biochemical support for the monolayer or three‐dimensional (3D) cultured cells but also assist in cell adhesion and cell‐to‐cell communication. They play important roles in directing the differentiation of PSCs into neural cells and modeling neurological diseases. For the trans‐differentiation of neural cells, several materials have been used to make the conversion feasible for future therapy. Here, the most current applications of materials for neural differentiation for PSCs, neuronal trans‐differentiation, and neurological disease modeling is summarized and discussed.