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Necklace‐Like Microfibers with Variable Knots and Perfusable Channels Fabricated by an Oil‐Free Microfluidic Spinning Process
Author(s) -
Xie Ruoxiao,
Xu Peidi,
Liu Yupeng,
Li Lili,
Luo Guoan,
Ding Mingyu,
Liang Qionglin
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201705082
Subject(s) - microfiber , materials science , spinning , microfluidics , nanotechnology , biomimetics , composite material
Fiber materials with different structural features, which in many cases endow the fibers extraordinary functions, are drawing considerable attention from biomedical and material researchers. Here, perfusable necklace‐like knotted microfibers are presented for the first time. Additionally, a novel microfluidic spinning method facilitates the production of variable knots and channels. Not only spindle‐, but also hemisphere‐ and petal‐knotted microfibers can be controllably fabricated. Generation and perfusion of both Janus channels and helical channel in the knotted microfibers are also shown. With no need of oil and surfactant, the spinning process is highly cytocompatible. The potential bioengineering and biomedical application of the knotted hollow microfiber is demonstrated by its cell‐encapsulation feasibility and the unique liver acinus‐like diffusion gradient in the knot. The merits of perfusability, cytocompatibility, and structural diversity of the microfibers may open more avenues for further material and biomedical investigation.