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Toxic Reactive Oxygen Species Enhanced Synergistic Combination Therapy by Self‐Assembled Metal‐Phenolic Network Nanoparticles
Author(s) -
Dai Yunlu,
Yang Zhen,
Cheng Siyuan,
Wang Zhongliang,
Zhang Ruili,
Zhu Guizhi,
Wang Zhantong,
Yung Bryant C.,
Tian Rui,
Jacobson Orit,
Xu Can,
Ni Qianqian,
Song Jibin,
Sun Xiaolian,
Niu Gang,
Chen Xiaoyuan
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201704877
Subject(s) - reactive oxygen species , prodrug , doxorubicin , nicotinamide adenine dinucleotide phosphate , radical , nanomedicine , materials science , combinatorial chemistry , nanoparticle , chemistry , biochemistry , nanotechnology , chemotherapy , enzyme , biology , genetics , oxidase test
Engineering functional nanomaterials with high therapeutic efficacy and minimum side effects has increasingly become a promising strategy for cancer treatment. Herein, a reactive oxygen species (ROS) enhanced combination chemotherapy platform is designed via a biocompatible metal‐polyphenol networks self‐assembly process by encapsulating doxorubicin (DOX) and platinum prodrugs in nanoparticles. Both DOX and platinum drugs can activate nicotinamide adenine dinucleotide phosphate oxidases, generating superoxide radicals (O 2 •− ). The superoxide dismutase‐like activity of polyphenols can catalyze H 2 O 2 generation from O 2 •− . Finally, the highly toxic HO • free radicals are generated by a Fenton reaction. The ROS HO • can synergize the chemotherapy by a cascade of bioreactions. Positron emission tomography imaging of 89 Zr‐labeled as‐prepared DOX@Pt prodrug Fe 3+ nanoparticles (DPPF NPs) shows prolonged blood circulation and high tumor accumulation. Furthermore, the DPPF NPs can effectively inhibit tumor growth and reduce the side effects of anticancer drugs. This study establishes a novel ROS promoted synergistic nanomedicine platform for cancer therapy.