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Activatable Hybrid Nanotheranostics for Tetramodal Imaging and Synergistic Photothermal/Photodynamic Therapy
Author(s) -
Goel Shreya,
Ferreira Carolina A.,
Chen Feng,
Ellison Paul A.,
Siamof Cerise M.,
Barnhart Todd E.,
Cai Weibo
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201704367
Subject(s) - photodynamic therapy , photothermal therapy , materials science , nanotechnology , porphyrin , cancer therapy , biocompatible material , nanoparticle , radiation therapy , surface modification , positron emission tomography , fluorescence lifetime imaging microscopy , mesoporous silica , biomedical engineering , fluorescence , cancer , mesoporous material , chemistry , nuclear medicine , medicine , photochemistry , radiology , optics , biochemistry , physics , organic chemistry , catalysis
A multifunctional core–satellite nanoconstruct is designed by assembling copper sulfide (CuS) nanoparticles on the surface of [ 89 Zr]‐labeled hollow mesoporous silica nanoshells filled with porphyrin molecules, for effective cancer imaging and therapy. The hybrid nanotheranostic demonstrates three significant features: (1) simple and robust construction from biocompatible building blocks, demonstrating prolonged blood retention, enhanced tumor accumulation, and minimal long‐term systemic toxicity, (2) rationally selected functional moieties that interact together to enable simultaneous tetramodal (positron emission tomography/fluorescence/Cerenkov luminescence/Cerenkov radiation energy transfer) imaging for rapid and accurate delineation of tumors and multimodal image‐guided therapy in vivo, and (3) synergistic interaction between CuS‐mediated photothermal therapy and porphyrin‐mediated photodynamic therapy which results in complete tumor elimination within a day of treatment with no visible recurrence or side effects. Overall, this proof‐of‐concept study illustrates an efficient, generalized approach to design high‐performance core–satellite nanohybrids that can be easily tailored to combine a wide variety of imaging and therapeutic modalities for improved and personalized cancer theranostics in the future.