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A Swellable Microneedle Patch to Rapidly Extract Skin Interstitial Fluid for Timely Metabolic Analysis
Author(s) -
Chang Hao,
Zheng Mengjia,
Yu Xiaojun,
Than Aung,
Seeni Razina Z.,
Kang Rongjie,
Tian Jingqi,
Khanh Duong Phan,
Liu Linbo,
Chen Peng,
Xu Chenjie
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201702243
Subject(s) - interstitial fluid , biomedical engineering , materials science , skin patch , hyaluronic acid , medicine , pathology , anatomy
Skin interstitial fluid (ISF) is an emerging source of biomarkers for disease diagnosis and prognosis. Microneedle (MN) patch has been identified as an ideal platform to extract ISF from the skin due to its pain‐free and easy‐to‐administrated properties. However, long sampling time is still a serious problem which impedes timely metabolic analysis. In this study, a swellable MN patch that can rapidly extract ISF is developed. The MN patch is made of methacrylated hyaluronic acid (MeHA) and further crosslinked through UV irradiation. Owing to the supreme water affinity of MeHA, this MN patch can extract sufficient ISF in a short time without the assistance of extra devices, which remarkably facilitates timely metabolic analysis. Due to covalent crosslinked network, the MN patch maintains the structure integrity in the swelling hydrated state without leaving residues in skin after usage. More importantly, the extracted ISF metabolites can be efficiently recovered from MN patch by centrifugation for the subsequent offline analysis of metabolites such as glucose and cholesterol. Given the recent trend of easy‐to‐use point‐of‐care devices for personal healthcare monitoring, this study opens a new avenue for the development of MN‐based microdevices for sampling ISF and minimally invasive metabolic detection.