Premium
Photothermal Ring Integrated Intraocular Lens for High‐Efficient Eye Disease Treatment
Author(s) -
Lin YaoXin,
Hu XueFeng,
Zhao Yang,
Gao YuJuan,
Yang Chao,
Qiao ShengLin,
Wang Yi,
Yang PeiPei,
Yan Jiao,
Sui XinCe,
Qiao ZengYing,
Li LiLi,
Xie JiangBing,
Zhu SiQuan,
Wu XiaoChun,
Li Yongsheng,
Wang Lei,
Wang Hao
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201701617
Subject(s) - photothermal therapy , intraocular lens , materials science , biocompatibility , lens (geology) , nanorod , cataract surgery , intraocular lenses , biomedical engineering , posterior capsule opacification , nanomaterials , ophthalmology , nanotechnology , medicine , optics , phacoemulsification , visual acuity , physics , metallurgy
Posterior capsule opacification (PCO) is the most common complication after cataract surgery. So far, the only method for PCO treatment is the precisely focused laser surgery. However, it causes severe complications such as physical damages and neuron impairments. Here, a nanostructured photothermal ring integrated intraocular lens ( Nano‐IOLs ) is reported, in which the rim of commercially available IOLs ( C‐IOLs ) is decorated with silica coated Au nanorods (Au@SiO 2 ), for high‐efficient prevention of PCO after cataract surgery. The Nano‐IOLs is capable of eliminating the residual lens epithelial cells (LECs) around Nano‐IOLs under mild laser treatment and block the formation of disordered LECs fibrosis, which eventually leads to the loss of vision. The Nano‐IOLs shows good biocompatibility as well as extraordinary region‐confined photothermal effect. In vivo studies reveal that PCO occurrence in rabbit models is about 30%–40% by using Nano‐IOLs , which is significantly lower than the control group that treated with C‐IOLs (100% PCO occurrence) 30 d postsurgery. To the best of our knowledge, it is the first example to integrate nanotechnology with intraocular implants aiming to clinically relevant PCO. Our findings indicate that spatial controllability of photothermal effect from nanomaterials may provide a unique way to intervene the PCO‐induced loss of vision.