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A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer
Author(s) -
Hu Yanyan,
Chi Chongwei,
Wang Shunhao,
Wang Lingxiong,
Liang Ping,
Liu Fangyi,
Shang Wenting,
Wang Weiwei,
Zhang Fengrong,
Li Shanshan,
Shen Heyun,
Yu Xiaoling,
Liu Huiyu,
Tian Jie
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201700448
Subject(s) - pancreatic cancer , photothermal therapy , urokinase receptor , indocyanine green , medicine , materials science , cancer , pancreatic tumor , immunotherapy , oncology , cancer research , radiology , pathology , plasminogen activator , nanotechnology
Although nanoparticle‐based photothermal therapy (PTT) has been intensively investigated recently, its comparative efficiency with any clinical cancer treatments has been rarely explored. Herein for the first time we report a systematic comparative study of clinical iodine‐125 ( 125 I) interstitial brachytherapy (IBT‐125‐I) and interventional PTT (IPTT) in an orthotopic xenograft model of human pancreatic cancer. IPTT, based on the nanoparticles composing of anti‐urokinase plasminogen activator receptor (uPAR) antibody, polyethylene glycol (PEG), and indocyanine green (ICG) modified gold nanoshells (hereinafter uIGNs), is directly applied to local pancreatic tumor deep in the abdomen. In comparison to IBT‐125‐I, a 25% higher median survival rate of IPTT with complete ablation by one‐time intervention has been achieved. The IPTT could also inhibit pancreatic tumor metastasis which can be harnessed for effective cancer immunotherapy. All results show that this IPTT is a safe and radical treatment for eradicating tumor cells, and may benefit future clinical pancreatic cancer patients.