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Manganese‐Based Layered Double Hydroxide Nanoparticles as a T 1 ‐MRI Contrast Agent with Ultrasensitive pH Response and High Relaxivity
Author(s) -
Li Bei,
Gu Zi,
Kurniawan Nyoman,
Chen Weiyu,
Xu Zhi Ping
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201700373
Subject(s) - nanoparticle , hydroxide , materials science , manganese , mri contrast agent , gadolinium , magnetic resonance imaging , nanomaterials , absorption (acoustics) , nuclear magnetic resonance , nuclear chemistry , nanotechnology , chemistry , inorganic chemistry , medicine , physics , composite material , radiology , metallurgy
Recently, Mn(II)‐containing nanoparticles have been explored widely as an attractive alternative to Gd(III)‐based T 1 ‐weighted magnetic resonance imaging (MRI) contrast agents (CAs) for cancer diagnosis. However, as far as it is known, no Mn‐based MRI CAs have been reported to sensitively respond to a very weakly acidic environment (pH 6.5–7.0, i.e., the pH range in a tumor microenvironment) with satisfactory imaging performance. Here, recently devised pH‐ultrasensitive Mn‐based layered double hydroxide (Mn‐LDH) nanoparticles with superb longitudinal relaxivity (9.48 m m −1 s −1 at pH 5.0 and 6.82 m m −1 s −1 at pH 7.0 vs 1.16 m m −1 s −1 at pH 7.4) are reported, which may result from the unique microstructure of Mn ions in Mn‐LDH, as demonstrated by extended X‐ray absorption fine structure. Further in vivo imaging reveals that Mn‐LDH nanoparticles show clear MR imaging for tumor tissues in mice for 2 d post intravenous injection. Thus, this novel Mn‐doped LDH nanomaterial, together with already demonstrated capacity for drug and gene delivery, is a very potential theranostic agent for cancer diagnosis and treatment.