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Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery
Author(s) -
Han Sanyang,
Samanta Animesh,
Xie Xiaoji,
Huang Ling,
Peng Juanjuan,
Park Sung Jin,
Teh Daniel Boon Loong,
Choi Yongdoo,
Chang YoungTae,
All Angelo Homayoun,
Yang Yanmei,
Xing Bengang,
Liu Xiaogang
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201700244
Subject(s) - photon upconversion , materials science , photothermal therapy , nanotechnology , biocompatibility , drug delivery , colloidal gold , surface modification , nanoparticle , luminescence , optoelectronics , chemical engineering , engineering , metallurgy
Although multifunctional upconversion imaging probes have recently attracted considerable interest in biomedical research, there are currently few methods for stabilizing these luminescent nanoprobes with oligonucleotides in biological systems. Herein, a method to robustly disperse upconversion nanoprobes in physiological buffers based on rational design and synthesis of nanoconjugates comprising hairpin‐DNA‐modified gold nanoparticles is presented. This approach imparts the upconversion nanoprobes with excellent biocompatibility and circumvents the problem of particle agglomeration. By combining single‐band anti‐Stokes near‐infrared emission and the photothermal effect mediated by the coupling of gold to upconversion nanoparticles, a simple, versatile nanoparticulate system for simultaneous deep‐tissue imaging and drug molecule release in vivo is demonstrated.