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Self‐Adjusting, Polymeric Multilayered Roll that can Keep the Shapes of the Blood Vessel Scaffolds during Biodegradation
Author(s) -
Cheng Shiyu,
Jin Yu,
Wang Nuoxin,
Cao Feng,
Zhang Wei,
Bai Wei,
Zheng Wenfu,
Jiang Xingyu
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201700171
Subject(s) - materials science , biodegradation , plga , scaffold , layer (electronics) , polymer , polyester , biomedical engineering , tube (container) , in vivo , composite material , biodegradable polymer , nanotechnology , nanoparticle , medicine , chemistry , microbiology and biotechnology , organic chemistry , biology
A self‐adjusting, blood vessel‐mimicking, multilayered tubular structure with two polymers, poly(ε‐caprolactone) (PCL) and poly( dl ‐lactide‐ co ‐glycolide) (PLGA), can keep the shape of the scaffold during biodegradation. The inner (PCL) layer of the tube can expand whereas the outer (PLGA) layers will shrink to maintain the stability of the shape and the inner space of the tubular shape both in vitro and in vivo over months. This approach can be generally useful for making scaffolds that require the maintenance of a defined shape, based on FDA‐approved materials.