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Drug Delivery: Gd‐Hybridized Plasmonic Au‐Nanocomposites Enhanced Tumor‐Interior Drug Permeability in Multimodal Imaging‐Guided Therapy (Adv. Mater. 40/2016)
Author(s) -
Wang Jing,
Liu Jing,
Liu Ying,
Wang Liming,
Cao Mingjing,
Ji Yinglu,
Wu Xiaochun,
Xu Yingying,
Bai Bing,
Miao Qing,
Chen Chunying,
Zhao Yuliang
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201670285
Subject(s) - materials science , photothermal therapy , drug delivery , nanocomposite , plasmon , nanotechnology , permeability (electromagnetism) , drug , nanoparticle , biomedical engineering , optoelectronics , medicine , pharmacology , membrane , biology , genetics
On page 8950, Y. Zhao and co‐workers propose an insightful and attractive strategy for enhanced pathological permeability and retention (EPPR) effect in drug delivery. They fabricated a new Gd‐hybridized plasmonic gold nanocomposite and then used a novel strategy by plasmonic feature‐based localized and on‐off controlled photothermal properties to increase the transportation and permeability of the nanocomposite (loaded with imaging agents and drugs) in the tumor interior, achieving high‐sensitive multimodal imaging and simultaneously improving the therapeutic efficacy.