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Drug Delivery: Microneedles Integrated with Pancreatic Cells and Synthetic Glucose‐Signal Amplifiers for Smart Insulin Delivery (Adv. Mater. 16/2016)
Author(s) -
Ye Yanqi,
Yu Jicheng,
Wang Chao,
Nguyen NhuY,
Walker Glenn M.,
Buse John B.,
Gu Zhen
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201670112
Subject(s) - insulin delivery , calcein , materials science , drug delivery , rhodamine b , transdermal , signal (programming language) , amplifier , biomedical engineering , insulin , nanotechnology , optoelectronics , pharmacology , diabetes mellitus , medicine , biochemistry , computer science , endocrinology , type 1 diabetes , biology , cmos , photocatalysis , membrane , programming language , catalysis
A bio‐responsive microneedle‐based patch, integrated with a rhodamine‐stained glucose‐signal amplifier and calcein‐AM‐stained pancreatic β‐cell capsules, is developed by Z. Gu and co‐workers. This “smart cell patch”, described on page 3115, effectively regulates the blood glucose level of type‐1 diabetic mice, achieving a reduction for over 10 h. Image credit: Yanqi Ye.