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Gene Delivery: Fusogenic Reactive Oxygen Species Triggered Charge‐Reversal Vector for Effective Gene Delivery (Adv. Mater. 9/2016)
Author(s) -
Liu Xin,
Xiang Jiajia,
Zhu Dingcheng,
Jiang Liming,
Zhou Zhuxian,
Tang Jianbin,
Liu Xiangrui,
Huang Yongzhuo,
Shen Youqing
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201670057
Subject(s) - gene delivery , cationic polymerization , reactive oxygen species , intracellular , oxygen , doxorubicin , cytosol , biophysics , viral vector , materials science , vector (molecular biology) , polymer , gene , membrane , genetic enhancement , biology , nanotechnology , microbiology and biotechnology , biochemistry , polymer chemistry , chemistry , recombinant dna , genetics , organic chemistry , enzyme , chemotherapy , composite material
On page 1743, Y. Shen and co‐workers describe the design of a novel fusogenic lipidic polyplex (FLPP) vector, which fuses with cell membranes, mimicking viropexis and ejecting the polyplex into the cytosol. There, the cationic polymer is oxidized by intracellular reaction oxygen species, becomes negatively charged, and releases DNA efficiently. This vector delivering suicide genes achieves significantly better inhibition of tumor growth than doxorubicin, making it a candidate for further study in gene therapy and cancer treatment.