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Ratiometric Photoacoustic Molecular Imaging for Methylmercury Detection in Living Subjects
Author(s) -
Liu Yi,
Wang Sheng,
Ma Ying,
Lin Jing,
Wang HaiYan,
Gu Yueqing,
Chen Xiaoyuan,
Huang Peng
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201606129
Subject(s) - nanoprobe , photoacoustic imaging in biomedicine , absorbance , molecular imaging , materials science , cyanine , metal ions in aqueous solution , fluorescence , methylmercury , photochemistry , in vivo , chemistry , nanotechnology , metal , nanoparticle , chromatography , optics , selenium , physics , microbiology and biotechnology , metallurgy , biology
Photoacoustic molecular imaging is an emerging and promising diagnostic tool for heavy metal ions detection. Methylmercury (MeHg + ) is one of the most potent neurotoxins, which damages the brain and nervous system of human beings through fish consumption. The development of a selective and sensitive method for MeHg + detection is highly desirable. In this Communication, we develope a chemoselective photoacoustic sensor (LP‐hCy7) composed of the liposome (LP) and MeHg + ‐responsive near‐infrared (NIR) cyanine dye (hCy7) for MeHg + detection within living subjects, such as zebrafish and mouse. The as‐prepared LP‐hCy7 nanoprobe displays unique dual‐shift NIR absorbance peaks and produces a normalized turn‐on response after the reaction of MeHg + and hCy7 through a mercury‐promoted cyclization reaction. The absorbance intensities of LP‐hCy7 nanoprobe at 690 and 860 nm are decreased and increased, respectively. The ratiometric photoacoustic signal (PA860/PA690) is noticeably increased in the presence of MeHg + . These findings not only provide a ratiometric photoacoustic molecular imaging probe for the detection of metal ions in vivo, but also provides a tool for spectroscopic photoacoustic molecular imaging.