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Virus‐Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes
Author(s) -
Yang Yoosoo,
Hong Yeonsun,
Nam GiHoon,
Chung Jin Hwa,
Koh Eunee,
Kim InSan
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201605604
Subject(s) - membrane , microvesicles , vesicular stomatitis virus , integral membrane protein , biocompatible material , exosome , membrane protein , nanotechnology , materials science , virus , microbiology and biotechnology , biology , biophysics , virology , biochemistry , engineering , biomedical engineering , microrna , gene
An efficient system for direct delivery of integral membrane proteins is successfully developed using a new biocompatible exosome‐based platform. Fusogenic exosomes harboring viral fusogen, vascular stomatitis virus (VSV)‐G protein, can fuse with and modify plasma membranes in a process called “membrane editing.” This can facilitate the transfer of biologically active membrane proteins into the target cell membranes both in vitro and in vivo.