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Rabies Virus‐Inspired Silica‐Coated Gold Nanorods as a Photothermal Therapeutic Platform for Treating Brain Tumors
Author(s) -
Lee Changkyu,
Hwang Ha Shin,
Lee Sungin,
Kim Bomi,
Kim Jong Oh,
Oh Kyung Taek,
Lee Eun Seong,
Choi HanGon,
Youn Yu Seok
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201605563
Subject(s) - nanorod , rabies virus , photothermal therapy , materials science , rabies , nanotechnology , in vivo , photothermal effect , colloidal gold , virus , virology , nanoparticle , medicine , biology , microbiology and biotechnology
Rabies virus‐inspired silica‐coated gold nanorods are fabricated by mimicking size, shape, surface glycoprotein property and in vivo behavior of the rabies virus. These nanorods not only resemble the appearance of the actual rabies virus but also travel into the brain through the neuronal pathway bypassing the blood–brain barrier, and moreover respond to near‐infrared laser (808 nm) irradiation, emit heat, and effectively suppress brain tumors.