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Light‐Enhancing Plasmonic‐Nanopore Biosensor for Superior Single‐Molecule Detection
Author(s) -
Assad Ossama N.,
Gilboa Tal,
Spitzberg Joshua,
Juhasz Matyas,
Weinhold Elmar,
Meller Amit
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201605442
Subject(s) - nanopore , biosensor , materials science , plasmon , fluorescence , nanosensor , molecule , optoelectronics , excitation , nanotechnology , laser , optics , chemistry , physics , electrical engineering , organic chemistry , engineering
A stacked plasmonic nanowell–nanopore biosensor strongly suppresses the background fluorescence from the bulk and yields net more than tenfold enhancement of the fluorescence intensity. The device offers extremely high signal‐to‐background (S/B) ratio for single‐molecule detection at ultralow excitation laser intensities, while maintaining extremely high temporal bandwidth for single‐DNA sensing.