Light‐Enhancing Plasmonic‐Nanopore Biosensor for Superior Single‐Molecule Detection | Zendy

Assad Ossama N. | Zendy; Gilboa Tal | Zendy; Spitzberg Joshua | Zendy; Juhasz Matyas | Zendy; Weinhold Elmar | Zendy; Meller Amit | Zendy

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Light‐Enhancing Plasmonic‐Nanopore Biosensor for Superior Single‐Molecule Detection

Author(s) -

Assad Ossama N.,

Gilboa Tal,

Spitzberg Joshua,

Juhasz Matyas,

Weinhold Elmar,

Meller Amit

Publication year - 2017

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201605442

Subject(s) - nanopore , biosensor , materials science , plasmon , fluorescence , nanosensor , molecule , optoelectronics , excitation , nanotechnology , laser , optics , chemistry , physics , electrical engineering , organic chemistry , engineering

A stacked plasmonic nanowell–nanopore biosensor strongly suppresses the background fluorescence from the bulk and yields net more than tenfold enhancement of the fluorescence intensity. The device offers extremely high signal‐to‐background (S/B) ratio for single‐molecule detection at ultralow excitation laser intensities, while maintaining extremely high temporal bandwidth for single‐DNA sensing.

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