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Biomimetic Engineering Using Cancer Cell Membranes for Designing Compartmentalized Nanoreactors with Organelle‐Like Functions
Author(s) -
Balasubramanian Vimalkumar,
Correia Alexandra,
Zhang Hongbo,
Fontana Flavia,
Mäkilä Ermei,
Salonen Jarno,
Hirvonen Jouni,
Santos Hélder A.
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201605375
Subject(s) - nanoreactor , artificial cell , nanotechnology , materials science , organelle , membrane , computer science , nanoparticle , biology , microbiology and biotechnology , biochemistry
A new biomimetic nanoreactor design is presented based on cancer cell membrane material in combination with porous silicon nanoparticles. This cellular nanoreactor features a biocompartment enclosed by a cell membrane and readily integrated with cells and supplementing the cellular functions under oxidative stress. The study demonstrates the impact of the nanoreactors on improving cellular functions with a potential to serve as artificial organelles.