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A Difunctional Regeneration Scaffold for Knee Repair based on Aptamer‐Directed Cell Recruitment
Author(s) -
Hu Xiaoxia,
Wang Yulan,
Tan Yaning,
Wang Jie,
Liu Haoyang,
Wang Yingqian,
Yang Shuang,
Shi Miusi,
Zhao Shiyong,
Zhang Yufeng,
Yuan Quan
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201605235
Subject(s) - scaffold , regeneration (biology) , mesenchymal stem cell , aptamer , materials science , computer science , biomedical engineering , biology , microbiology and biotechnology , database , engineering
To solve the challenge of poor knee repair, an aptamer‐bilayer scaffold is designed for autologous mesenchymal stem cell (MSC) recruitment and osteochondral regeneration. The scaffold can efficiently recruit MSCs to the defect and induce the directional differentiation of MSCs, thus successfully achieving simultaneous regeneration of cartilage and bone in the knee joint.