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Amplified Photodegradation of Cell‐Laden Hydrogels via an Addition–Fragmentation Chain Transfer Reaction
Author(s) -
Brown Tobin E.,
Marozas Ian A.,
Anseth Kristi S.
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201605001
Subject(s) - photodegradation , self healing hydrogels , photoinitiator , materials science , kinetics , sulfide , chemical engineering , cell encapsulation , photochemistry , degradation (telecommunications) , polymer chemistry , polymer , catalysis , chemistry , organic chemistry , monomer , photocatalysis , composite material , telecommunications , physics , quantum mechanics , computer science , engineering , metallurgy
Hydrogels crosslinked by allyl‐sulfide‐containing molecules are presented. By exposure to light in the presence of a photoinitiator and a free monofunctional thiol, photodegradation is achieved. Both the gelation and degradation are cytocompatible and allow for cell encapsulation and subsequent release. The photodegradation kinetics and depths attainable are superior to those of traditional cell‐laden photodegradable hydrogels.