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Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma
Author(s) -
Chandrawati Rona,
Chang Jason Y. H.,
ReinaTorres Ester,
Jumeaux Coline,
Sherwood Joseph M.,
Stamer W. Daniel,
Zelikin Alexander N.,
Overby Darryl R.,
Stevens Molly M.
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201604932
Subject(s) - trabecular meshwork , glaucoma , intraocular pressure , nitric oxide , ophthalmology , schlemm's canal , latanoprost , outflow , medicine , aqueous humor , pharmacology , physics , meteorology
Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location‐ and dose‐dependent. A NO delivery platform that directly targets the resistance‐generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model.