Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma | Zendy

Chandrawati Rona | Zendy; Chang Jason Y. H. | Zendy; ReinaTorres Ester | Zendy; Jumeaux Coline | Zendy; Sherwood Joseph M. | Zendy; Stamer W. Daniel | Zendy; Zelikin Alexander N. | Zendy; Overby Darryl R. | Zendy; Stevens Molly M. | Zendy

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Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma

Author(s) -

Chandrawati Rona,

Chang Jason Y. H.,

ReinaTorres Ester,

Jumeaux Coline,

Sherwood Joseph M.,

Stamer W. Daniel,

Zelikin Alexander N.,

Overby Darryl R.,

Stevens Molly M.

Publication year - 2017

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201604932

Subject(s) - biocatalysis , materials science , nitric oxide , glaucoma , enzyme , nanotechnology , medicine , biochemistry , ophthalmology , catalysis , biology , ionic liquid

Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location‐ and dose‐dependent. A NO delivery platform that directly targets the resistance‐generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model.

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