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Thiol–Ene Click Reaction as a Facile and General Approach for Surface Functionalization of Colloidal Nanocrystals
Author(s) -
Liu Bin,
Deng Xiaoran,
Xie Zhongxi,
Cheng Ziyong,
Yang Piaoping,
Lin Jun
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201604878
Subject(s) - surface modification , oleylamine , click chemistry , materials science , ethylene glycol , covalent bond , nanotechnology , nanocrystal , ene reaction , thiol , luminescence , bioconjugation , combinatorial chemistry , chemical engineering , polymer chemistry , organic chemistry , chemistry , optoelectronics , engineering
Oleic acid (OA) and/or oleylamine (OAm) are generally used as the surface ligands for stabilization of inorganic nanocrystals (NCs). The hydrophobic and inert surface of the NCs limits their applications such as in biomedical areas. Hence, surface modifications are essential in many physical and chemical processes. Here, a facile and versatile strategy is reported for the modification of NCs by ultraviolet‐induced thiol–ene chemistry, in which thiol‐terminated poly(ethylene glycol) (HSPEG) and its derivatives can react directly with double bonds in OA/OAm ligands to form covalent linking within one step. Through this strategy, various hydrophobic NCs with different compositions and morphologies are able to be transferred into water combining with functionalization of active groups. As a proof‐of‐concept, this strategy is successfully used to construct a sensor for detecting avidin based on upconverting luminescence analysis. Therefore, this strategy provides a new tool for designing and tuning the surface properties of NCs for different applications.