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Genome‐Wide DNA Methylation Variations upon Exposure to Engineered Nanomaterials and Their Implications in Nanosafety Assessment
Author(s) -
Chen Yue,
Xu Ming,
Zhang Jie,
Ma Juan,
Gao Ming,
Zhang Zhihong,
Xu Yong,
Liu Sijin
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201604580
Subject(s) - dna methylation , computational biology , dna , methylation , nanomaterials , nanotechnology , biology , computer science , materials science , genetics , gene , gene expression
Sublethal exposure of engineered nanomaterials (ENMs) induces the alteration of various cellular processes due to DNA methylation changes. DNA methylation variations represent a more sensitive fingerprint analysis of the direct and indirect effects that may be overlooked by traditional toxicity assays, and an understanding of the structure–activity relationship of DNA methylation upon ENMs would open a new path for their safer design.