Premium
Nanopolymersomes with an Ultrahigh Iodine Content for High‐Performance X‐Ray Computed Tomography Imaging In Vivo
Author(s) -
Zou Yan,
Wei Yaohua,
Wang Guanglin,
Meng Fenghua,
Gao Mingyuan,
Storm Gert,
Zhong Zhiyuan
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201603997
Subject(s) - in vivo , iohexol , iodine , materials science , biocompatible material , contrast (vision) , content (measure theory) , computed tomography , content delivery , biomedical engineering , medical physics , nuclear medicine , computer science , nanotechnology , medicine , radiology , artificial intelligence , biology , mathematics , renal function , mathematical analysis , microbiology and biotechnology , metallurgy , computer network
Biocompatible and biodegradable nanopolymersomes with an unprecedented iodine content, low viscosity, and iso‐osmolality achieve significantly enhanced CT imaging of blood pool and the reticuloendothelial system. Moreover, in subcutaneous and orthotopic tumor models in mice, they show enhanced in vivo imaging when compared to iohexol, a clinically used small‐molecule contrast agent.