An Amphiphilic Ruthenium Polymetallodrug for Combined Photodynamic Therapy and Photochemotherapy In Vivo | Zendy

Sun Wen | Zendy; Li Shuyi | Zendy; Häupler Bernhard | Zendy; Liu Juan | Zendy; Jin Shubin | Zendy; Steffen Werner | Zendy; Schubert Ulrich S. | Zendy; Butt HansJürgen | Zendy; Liang XingJie | Zendy; Wu Si | Zendy

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An Amphiphilic Ruthenium Polymetallodrug for Combined Photodynamic Therapy and Photochemotherapy In Vivo

Author(s) -

Sun Wen,

Li Shuyi,

Häupler Bernhard,

Liu Juan,

Jin Shubin,

Steffen Werner,

Schubert Ulrich S.,

Butt HansJürgen,

Liang XingJie,

Wu Si

Publication year - 2017

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201603702

Subject(s) - amphiphile , ruthenium , copolymer , in vivo , materials science , photodynamic therapy , nanoparticle , combinatorial chemistry , nanotechnology , chemistry , organic chemistry , catalysis , biology , polymer , microbiology and biotechnology , composite material

An amphiphilic Ru‐containing block copolymer is used as a photoactivated polymetallodrug for anticancer phototherapy. The block copolymer self‐assembles into nanoparticles, which can accumulate at tumor sites in a mouse model. Red light irradiation of the block copolymer nanoparticles releases anticancer Ru complexes and generates cytotoxic 1 O 2 , both of which can inhibit tumor growth.

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