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An Amphiphilic Ruthenium Polymetallodrug for Combined Photodynamic Therapy and Photochemotherapy In Vivo
Author(s) -
Sun Wen,
Li Shuyi,
Häupler Bernhard,
Liu Juan,
Jin Shubin,
Steffen Werner,
Schubert Ulrich S.,
Butt HansJürgen,
Liang XingJie,
Wu Si
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201603702
Subject(s) - amphiphile , ruthenium , copolymer , in vivo , materials science , photodynamic therapy , nanoparticle , combinatorial chemistry , nanotechnology , chemistry , organic chemistry , catalysis , biology , polymer , microbiology and biotechnology , composite material
An amphiphilic Ru‐containing block copolymer is used as a photoactivated polymetallodrug for anticancer phototherapy. The block copolymer self‐assembles into nanoparticles, which can accumulate at tumor sites in a mouse model. Red light irradiation of the block copolymer nanoparticles releases anticancer Ru complexes and generates cytotoxic 1 O 2 , both of which can inhibit tumor growth.