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Layer‐by‐Layer Encapsulation of Probiotics for Delivery to the Microbiome
Author(s) -
Anselmo Aaron C.,
McHugh Kevin J.,
Webster Jamie,
Langer Robert,
Jaklenec Ana
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201603270
Subject(s) - probiotic , microbiome , encapsulation (networking) , materials science , gut microbiome , nanotechnology , gastrointestinal tract , biology , bioinformatics , bacteria , computer science , biochemistry , computer network , genetics
The gastrointestinal (GI) microbiome is widely investigated for its role in many diseases. However, technologies designed for microbiome delivery are lacking. Here, a layer‐by‐layer (LbL) approach is reported for probiotic encapsulation to protect probiotics against GI tract insults and improve their adhesion and growth on the intestines. These advantages translate to significantly enhanced survival of LbL‐probiotics in vivo.