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Multistaged Nanovaccines Based on Porous Silicon@Acetalated Dextran@Cancer Cell Membrane for Cancer Immunotherapy
Author(s) -
Fontana Flavia,
Shahbazi MohammadAli,
Liu Dongfei,
Zhang Hongbo,
Mäkilä Ermei,
Salonen Jarno,
Hirvonen Jouni T.,
Santos Hélder A.
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201603239
Subject(s) - materials science , cancer , dextran , membrane , chemical engineering , cancer immunotherapy , silicon , immunotherapy , porous silicon , porosity , nanotechnology , chromatography , composite material , metallurgy , medicine , biochemistry , biology , chemistry , engineering
Immunoadjuvant porous silicon (PSi)‐based nanovaccines are prepared by nanoprecipitation in a glass capillary microfluidics device. Vesicles, derived from cancer cell membranes encapsulating thermally oxidized PSi nanoparticles or PSi‐polymer nanosystems binding a model antigen, are biocompatible over a wide range of concentrations, and show immunostimulant properties in human cells, promoting the expression of co‐stimulatory signals and the secretion of pro‐inflammatory cytokines.