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Fabrication of RNA 3D Nanoprisms for Loading and Protection of Small RNAs and Model Drugs
Author(s) -
Khisamutdinov Emil F.,
Jasinski Daniel L.,
Li Hui,
Zhang Kaiming,
Chiu Wah,
Guo Peixuan
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201603180
Subject(s) - fabrication , rna , nanotechnology , materials science , content delivery , small molecule , computer science , biology , gene , biochemistry , computer network , medicine , alternative medicine , pathology
Constructing containers with defined shape and size to load and protect therapeutics and subsequently control their release in the human body has long been a dream. The fabrication of 3D RNA prisms, characterized by atomic force microscopy, cryo‐electron microscopy, dynamic light scattering, and polyacrylamide gel electrophoresis, is reported for the loading and protection of small molecules, proteins, small RNA molecules, and their controlled release.