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In Situ Observation of Single‐Molecule Surface Reactions from Low to High Affinities
Author(s) -
Kim Eugene,
Baaske Martin D.,
Vollmer Frank
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201603153
Subject(s) - affinities , materials science , in situ , surface modification , molecule , surface plasmon resonance , nanotechnology , nanorod , chemical physics , photochemistry , nanoparticle , stereochemistry , chemistry , organic chemistry
In situ observation of single‐molecule surface reactions from low to high affinities is achieved by resonant coupling between optical whispering‐gallery modes and the localized surface plasmon of nanorods. Transient and permanent interactions between ligands (thiol, amine) and the gold surface are monitored without labels, allowing direct determination of the associated kinetic constants and rapid development of new functionalization protocols.