Premium
AuNP–Collagen Matrix with Localized Stiffness for Cardiac‐Tissue Engineering: Enhancing the Assembly of Intercalated Discs by β1‐Integrin‐Mediated Signaling
Author(s) -
Li Yi,
Shi Xiaoli,
Tian Lei,
Sun Hongyu,
Wu Yujing,
Li Xia,
Li Jianjun,
Wei Yujie,
Han Xinxiao,
Zhang Jiao,
Jia Xiaowei,
Bai Rui,
Jing Limin,
Ding Peng,
Liu Huiliang,
Han Dong
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201603027
Subject(s) - materials science , integrin , microbiology and biotechnology , integrin linked kinase , signal transduction , schematic , colloidal gold , matrix (chemical analysis) , kinase , nanotechnology , biophysics , protein kinase a , nanoparticle , biology , biochemistry , receptor , cyclin dependent kinase 2 , composite material , electronic engineering , engineering
A schematic for the mechanism of accelerating the assembly of intercalated discs (IDs) in cardiac myocytes regulated by gold nanoparticles (AuNPs) is presented. AuNPs with local nanoscale stiffness in the substrate activate β1‐integrin signaling, which mediates the activation of integrin‐linked kinase (ILK) and its downstream signal kinase by stimulating expression of the transcription factors GATA4 and MEF‐2c.