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Exploiting Noncovalent Interactions in an Imine‐Based Covalent Organic Framework for Quercetin Delivery
Author(s) -
Vyas Vijay S.,
Vishwakarma Medhavi,
Moudrakovski Igor,
Haase Frederik,
Savasci Gökcen,
Ochsenfeld Christian,
Spatz Joachim P.,
Lotsch Bettina V.
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201603006
Subject(s) - covalent organic framework , nanocarriers , drug delivery , nanotechnology , materials science , imine , covalent bond , non covalent interactions , nanoporous , biocompatibility , computer science , combinatorial chemistry , chemistry , organic chemistry , hydrogen bond , molecule , metallurgy , catalysis
Covalent organic frameworks (COFs) are a new class of nanoporous polymeric vector showing promise as drug‐delivery vehicles with high loading capacity and biocompatibility. The interaction between the carrier and the cargo is specifically tailored on a molecular level by H‐bonding. Cell‐proliferation studies indicate higher efficacy of the drug in cancer cells by nanocarrier delivery mediated by the COF.