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Nanoscale Polymer Metal–Organic Framework Hybrids for Effective Photothermal Therapy of Colon Cancers
Author(s) -
Wang Weiqi,
Wang Lei,
Li Yang,
Liu Shi,
Xie Zhigang,
Jing Xiabin
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201602997
Subject(s) - photothermal therapy , materials science , nucleation , endocytosis , nanoscopic scale , nanotechnology , polymerization , polymer , in vivo , aqueous solution , aniline , chemical engineering , organic chemistry , composite material , chemistry , biochemistry , microbiology and biotechnology , biology , engineering , cell
A UiO‐66 core with various sizes acts as heterogeneous nucleation center and enables aniline polymerization under ambient conditions. The as‐synthesized UiO‐66@PAN possesses uniform size and excellent dispersibility in aqueous solution. UiO‐66@PAN can be internalized by cancer cells via endocytosis, and indicates significant photothermal therapeutic effect in vitro, and can effectively inhibit the growth of colon cancers in vivo.