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Injectable and Cytocompatible Tough Double‐Network Hydrogels through Tandem Supramolecular and Covalent Crosslinking
Author(s) -
Rodell Christopher B.,
Dusaj Neville N.,
Highley Christopher B.,
Burdick Jason A.
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201602268
Subject(s) - self healing hydrogels , materials science , covalent bond , supramolecular chemistry , cell encapsulation , hyaluronic acid , self healing , nanotechnology , chemical engineering , polymer chemistry , molecule , organic chemistry , chemistry , medicine , alternative medicine , pathology , biology , engineering , genetics
Double‐network theory is extended to include guest–host interactions, enabling injectability and cytcompatibility of tough hydrogels. Noncovalent interactions are used as a sacrificial network to toughen covalently crosslinked hydrogels formed from hyaluronic acid. Shear thinning of supramolecular bonds allows hydrogel injection and rapid self‐healing, while gentle reaction conditions permit cell encapsulation with high viability.