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Catalase‐Loaded TaOx Nanoshells as Bio‐Nanoreactors Combining High‐Z Element and Enzyme Delivery for Enhancing Radiotherapy
Author(s) -
Song Guosheng,
Chen Yuyan,
Liang Chao,
Yi Xuan,
Liu Jingjing,
Sun Xiaoqi,
Shen Sida,
Yang Kai,
Liu Zhuang
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201602111
Subject(s) - nanoreactor , nanoshell , materials science , nanotechnology , radiation therapy , catalase , enzyme , chemistry , nanoparticle , biochemistry , medicine
A novel type of bio‐nanoreactor with catalase loaded inside TaOx hollow nanoshells is fabricated via a mild one‐step method. Such bio‐nanoreactors could efficiently improve the tumor oxygenation by supplying oxygen via decomposition of endogenic H 2 O 2 in a tumor microenvironment, and thus synergistically enhance the efficacy of cancer radiotherapy by both depositing radiation energy within the tumor and overcoming hypoxia‐induced radiotherapy resistance.