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Intelligent Albumin–MnO 2 Nanoparticles as pH‐/H 2 O 2 ‐Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy
Author(s) -
Chen Qian,
Feng Liangzhu,
Liu Jingjing,
Zhu Wenwen,
Dong Ziliang,
Wu Yifan,
Liu Zhuang
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201601902
Subject(s) - nanocarriers , nanoparticle , materials science , nanotechnology , tumor microenvironment , drug delivery , tumor hypoxia , computer science , tumor cells , cancer research , biology , medicine , radiation therapy
A unique type of pH/H 2 O 2 dual‐responsive intelligent nanoscale delivery system based on albumin‐coated MnO 2 is presented, which is capable of modulating the tumor microenvironment (TME) by relieving hypoxia. Additionally, TME‐responsive size changes enable effective intratumor diffusion. A highly effective combined photodynamic and chemotherapy is realized with these nanoparticles in a mouse tumor model.