Intelligent Albumin–MnO 2  Nanoparticles as pH‐/H 2 O 2 ‐Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy | Zendy

Chen Qian | Zendy; Feng Liangzhu | Zendy; Liu Jingjing | Zendy; Zhu Wenwen | Zendy; Dong Ziliang | Zendy; Wu Yifan | Zendy; Liu Zhuang | Zendy

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Intelligent Albumin–MnO 2 Nanoparticles as pH‐/H 2 O 2 ‐Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

Author(s) -

Chen Qian,

Feng Liangzhu,

Liu Jingjing,

Zhu Wenwen,

Dong Ziliang,

Wu Yifan,

Liu Zhuang

Publication year - 2016

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201601902

Subject(s) - nanocarriers , nanoparticle , materials science , nanotechnology , tumor microenvironment , drug delivery , tumor hypoxia , computer science , tumor cells , cancer research , biology , medicine , radiation therapy

A unique type of pH/H 2 O 2 dual‐responsive intelligent nanoscale delivery system based on albumin‐coated MnO 2 is presented, which is capable of modulating the tumor microenvironment (TME) by relieving hypoxia. Additionally, TME‐responsive size changes enable effective intratumor diffusion. A highly effective combined photodynamic and chemotherapy is realized with these nanoparticles in a mouse tumor model.

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