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Triboelectric Nanogenerator Accelerates Highly Efficient Nonviral Direct Conversion and In Vivo Reprogramming of Fibroblasts to Functional Neuronal Cells
Author(s) -
Jin Yoonhee,
Seo Jungmok,
Lee Jung Seung,
Shin Sera,
Park HyunJi,
Min Sungjin,
Cheong Eunji,
Lee Taeyoon,
Cho SeungWoo
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201601900
Subject(s) - reprogramming , triboelectric effect , in vivo , nanotechnology , materials science , stimulation , neuroscience , cell , microbiology and biotechnology , biology , genetics , composite material
Triboelectric nanogenerators (TENGs) can be an effective cell reprogramming platform for producing functional neuronal cells for therapeutic applications. Triboelectric stimulation accelerates nonviral direct conversion of functional induced neuronal cells from fibroblasts, increases the conversion efficiency, and induces highly matured neuronal phenotypes with improved electrophysiological functionalities. TENG devices may also be used for biomedical in vivo reprogramming.