A Powerful CD8 +  T‐Cell Stimulating D‐Tetra‐Peptide Hydrogel as a Very Promising Vaccine Adjuvant | Zendy

Luo Zichao | Zendy; Wu Qinjie | Zendy; Yang Chengbiao | Zendy; Wang Huaimin | Zendy; He Tao | Zendy; Wang Youzhi | Zendy; Wang Zhongyan | Zendy; Chen Hao | Zendy; Li Xingyi | Zendy; Gong Changyang | Zendy; Yang Zhimou | Zendy

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A Powerful CD8 + T‐Cell Stimulating D‐Tetra‐Peptide Hydrogel as a Very Promising Vaccine Adjuvant

Author(s) -

Luo Zichao,

Wu Qinjie,

Yang Chengbiao,

Wang Huaimin,

He Tao,

Wang Youzhi,

Wang Zhongyan,

Chen Hao,

Li Xingyi,

Gong Changyang,

Yang Zhimou

Publication year - 2017

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201601776

Subject(s) - adjuvant , peptide , supramolecular chemistry , cd8 , tetra , cytotoxic t cell , materials science , virology , nanotechnology , antigen , cancer research , computer science , computational biology , in vitro , medicine , immunology , biology , chemistry , biochemistry , molecule , organic chemistry , paleontology

A novel vaccine adjuvant based on a supramolecular hydrogel of a D‐tetra‐peptide is reported. Antigens can be easily incorporated into the hydrogel by a vortex or by gently shaking before injection. The vaccines can stimulate strong CD8+ T‐cell responses, which significantly inhibits tumor growth. This novel adjuvant is expected to enable a wide range of sub‐unit vaccines and help the production of antibodies.

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