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A Powerful CD8 + T‐Cell Stimulating D‐Tetra‐Peptide Hydrogel as a Very Promising Vaccine Adjuvant
Author(s) -
Luo Zichao,
Wu Qinjie,
Yang Chengbiao,
Wang Huaimin,
He Tao,
Wang Youzhi,
Wang Zhongyan,
Chen Hao,
Li Xingyi,
Gong Changyang,
Yang Zhimou
Publication year - 2017
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201601776
Subject(s) - adjuvant , peptide , supramolecular chemistry , cd8 , tetra , cytotoxic t cell , materials science , virology , nanotechnology , antigen , cancer research , computer science , computational biology , in vitro , medicine , immunology , biology , chemistry , biochemistry , molecule , organic chemistry , paleontology
A novel vaccine adjuvant based on a supramolecular hydrogel of a D‐tetra‐peptide is reported. Antigens can be easily incorporated into the hydrogel by a vortex or by gently shaking before injection. The vaccines can stimulate strong CD8+ T‐cell responses, which significantly inhibits tumor growth. This novel adjuvant is expected to enable a wide range of sub‐unit vaccines and help the production of antibodies.