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Polymer Capsules for Plaque‐Targeted In Vivo Delivery
Author(s) -
Richardson Joseph J.,
Choy Mei Y.,
Guo Junling,
Liang Kang,
Alt Karen,
Ping Yuan,
Cui Jiwei,
Law Lok S.,
Hagemeyer Christoph E.,
Caruso Frank
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201601754
Subject(s) - polymer , materials science , biopolymer , peg ratio , in vivo , drug delivery , targeted drug delivery , capsule , nanotechnology , synthetic polymer , molecule , biomedical engineering , chemistry , organic chemistry , medicine , composite material , botany , microbiology and biotechnology , finance , economics , biology
Targeted polymer capsules can selectively bind to unstable plaques in mice after intravenous injection. Different formulations of the capsules are explored with a synthetic/biopolymer hybrid capsule showing the best stability and small‐molecule drug retention. The synthetic polymer is composed of pH‐sensitive blocks (PDPA), low‐binding blocks (PEG), and click‐groups for postfunctionalization with targeting peptides specific to plaques.