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Biomimetic Immuno‐Magnetosomes for High‐Performance Enrichment of Circulating Tumor Cells
Author(s) -
Xiong Ke,
Wei Wei,
Jin Yongjie,
Wang Shumin,
Zhao Dongxu,
Wang Shuang,
Gao Xiaoyong,
Qiao Chenmeng,
Yue Hua,
Ma Guanghui,
Xie HaiYan
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201601643
Subject(s) - magnetosome , avidity , nanotechnology , materials science , magnetite , computer science , computational biology , microbiology and biotechnology , biology , antibody , immunology , metallurgy
A novel biomimetic immuno‐magnetosome (IMS) is developed by coating a leukocyte membrane (decorated with anti‐epithelial cell‐adhesion molecule antibody) on a magnetic nanocluster. In addition to the good stability and magnetic controllability, the IMS also exhibits satisfactory binding avidity to circulating tumor cells but stealth property to leukocytes. As a result, rare tumor cells can be effectively enriched with undetectable leukocyte background.