Biomimetic Immuno‐Magnetosomes for High‐Performance Enrichment of Circulating Tumor Cells | Zendy

Xiong Ke | Zendy; Wei Wei | Zendy; Jin Yongjie | Zendy; Wang Shumin | Zendy; Zhao Dongxu | Zendy; Wang Shuang | Zendy; Gao Xiaoyong | Zendy; Qiao Chenmeng | Zendy; Yue Hua | Zendy; Ma Guanghui | Zendy; Xie HaiYan | Zendy

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Biomimetic Immuno‐Magnetosomes for High‐Performance Enrichment of Circulating Tumor Cells

Author(s) -

Xiong Ke,

Wei Wei,

Jin Yongjie,

Wang Shumin,

Zhao Dongxu,

Wang Shuang,

Gao Xiaoyong,

Qiao Chenmeng,

Yue Hua,

Ma Guanghui,

Xie HaiYan

Publication year - 2016

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201601643

Subject(s) - magnetosome , avidity , nanotechnology , materials science , magnetite , computer science , computational biology , microbiology and biotechnology , biology , antibody , immunology , metallurgy

A novel biomimetic immuno‐magnetosome (IMS) is developed by coating a leukocyte membrane (decorated with anti‐epithelial cell‐adhesion molecule antibody) on a magnetic nanocluster. In addition to the good stability and magnetic controllability, the IMS also exhibits satisfactory binding avidity to circulating tumor cells but stealth property to leukocytes. As a result, rare tumor cells can be effectively enriched with undetectable leukocyte background.

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