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Activatable Fluorescent Nanoprobe with Aggregation‐Induced Emission Characteristics for Selective In Vivo Imaging of Elevated Peroxynitrite Generation
Author(s) -
Song Zhegang,
Mao Duo,
Sung Simon H. P.,
Kwok Ryan T. K.,
Lam Jacky W. Y.,
Kong Deling,
Ding Dan,
Tang Ben Zhong
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201601214
Subject(s) - nanoprobe , aggregation induced emission , in vivo , fluorescence , peroxynitrite , materials science , nanotechnology , biophysics , chemistry , nanoparticle , biochemistry , biology , physics , microbiology and biotechnology , quantum mechanics , enzyme , superoxide
An activatable fluorescent nanoprobe with aggregation‐induced emission signature is developed. The nanoprobe is nonfluorescent, but can be induced to emit intensely after reaction with peroxynitrite forming an intramolecular hydrogen bond. Excellent performance for selective in vivo imaging of inflammation with elevated peroxynitrite generation and efficient visualization of in vivo treatment efficacy of anti‐inflammatory agents is demonstrated.